The USS Macon was built at the Goodyear Airdock in Springfield Township, Ohio by the Goodyear-Zeppelin Corporation. Because this was by far the biggest airship ever to be built in America, a team of experienced German airship engineers—led by Chief Designer Karl Arnstein—instructed and supported design and construction of both the U.S. Navy airships Akron and Macon.

The Macon had a structured duraluminum hull with three interior keels. The airship was kept aloft by 12 helium-filled gas cells made from gelatin-latex fabric. Inside the hull, the ship had eight German-made Maybach 12-cylinder, 560 hp (418 kW) gasoline-powered engines that drove outside propellers. The propellers could be rotated down or backwards, providing an early form of thrust vectoring to control the ship during takeoff and landings. The rows of slots in the hull above each engine were part of a system to condense out the water vapor from the engine exhaust gases for use as buoyancy compensation ballast to compensate for the loss of weight as fuel was consumed.